RESUMO
BACKGROUND: Hypersensitivity reactions to anticancer chemotherapy and monoclonal antibodies may lead to discontinuation of first-line treatment options. Identification of these reactions can provide specific diagnosis and treatment by rapid drug desensitizations. OBJECTIVE: To determine the hypersensitivity reactions involved in anticancer chemotherapy and monoclonal antibodies, and the safety and efficacy of rapid drug desensitization. METHODS: We conducted an observational study of hypersensitivity reaction presented after the administration of anticancer chemotherapy and monoclonal antibodies in Mexico. We documented the symptoms of initial reaction and their severity, and the results of skin tests. We also report our experience of the administration of 12-step (mild-moderate reactions) and 16-step (severe reactions) desensitization protocols in these patients. RESULTS: Overall, 93 patients received 336 rapid drug desensitization; 105 to taxanes, 115 to platinum drugs, 101 to monoclonal antibodies, and 15 other anticancer chemotherapy. Hypersensitivity reaction to taxanes occurred in the first or second administration, platinum drugs after the sixth cycle, and rituximab in the first cycle. The most common symptom in carboplatin was urticaria, paclitaxel back pain, oxaliplatin and docetaxel dyspnea, and in the monoclonal antibodies cardiovascular symptoms. Skin tests were positive in 75% of the carboplatin group, and only 16.7% in docetaxel. There was a rapid drug desensitization success rate of 99.4% and 85.7% did not present any related hypersensitivity reaction. CONCLUSION: The diagnosis of hypersensitivity reaction to anticancer chemotherapy and monoclonal antibodies offers a panorama in the management of oncological diseases. Our standardized desensitization protocol is safe and effective and can be reproduced in other centers to treat patients who need to maintain first-line treatment.
RESUMO
OBJETIVO: Determinar la asociación entre tipología y disfuncionalidad familiar en familias mexicanas con adolescentes. DISEÑO: Estudio observacional de tipo transversal. EMPLAZAMIENTO Y PARTICIPANTES: Cuatrocientas treinta y siete familias con adolescentes inscritos en una escuela secundaria pública de una población mexicana. Mediciones principales: Determinación de la tipología familiar (Consejo y Consenso Mexicano de Medicina Familiar) y la funcionalidad familiar (APGAR familiar) en adolescentes y sus padres/tutores. Identificación de las familias con percepciones concordantes entre miembros (kappa de Cohen), en las cuales se determinó la asociación entre tipología y percepción de disfuncionalidad familiar (odds ratio [OR]). RESULTADOS: Los tipos de familias están asociados con la funcionalidad familiar por parentesco, presencia física en el hogar y el nivel de pobreza familiar. Desde la percepción del adolescente, se asocian los tipos: nuclear simple (OR 0,5, IC 95% 0,3-0,8), monoparental extendida (OR 1,9, IC 95% 1,03-3,5), núcleo integrado (OR 0,6, IC 95% 0,4-0,9), pobreza familiar baja (OR 0,5, IC 95% 0,3-0,8) y pobreza familiar alta (OR 5,3, IC 95% 1,5-18,6). Desde la percepción del tutor: la monoparental (OR 1,9, IC 95% 1,09-3,4) y de pobreza familiar alta (OR 2 9, IC 95% 1,1-7,7). Hubo 259 familias con percepción concordante de funcionalidad/disfuncionalidad familiar con un kappa = 0,189, determinando que los tipos asociados son: la nuclear simple (OR 0,4, IC 95% 0,2-0,7), monoparental (OR 1,7, IC 95% 0,80-3,8), núcleo integrado (OR 0,5, IC 95% 0,3-0,8), núcleo no integrado (OR 1,9, IC 95% 1,09-3,5) y pobreza familiar alta (OR 13,8, IC 95% 1,7-108,5). CONCLUSIÓN: Los tipos de familia con adolescentes asociadas con disfuncionalidad familiar son las monoparentales, las de núcleo no integrado y aquellas con pobreza familiar alta, y como factores de protección, la nuclear simple y con núcleo integrado
OBJECTIVE: To determine the association between family typology and dysfunction in families with adolescents in a Mexican population. DESIGN: Cross-sectional observational study. Setting and population: A total of 437 families in a Mexican population with adolescents attending a public high school. MAIN MEASUREMENTS: Determination of family typology (Mexican Family Medicine Council and Consensus) and family function (family APGAR) in adolescents and their parents/guardians. Identification of families with concordant perceptions among members (Cohen kappa), in which the association between typology and perception of family dysfunction was determined (odds ratio [OR]). RESULTS: The types of families are associated with family function by kinship, physical presence in the home and the level of family poverty. From the perception of the adolescent, the types are associated with: simple nuclear (OR 0.5, 95% CI 0.3-0.8), extended single parent (OR 1.9, 95% CI 1.03-3.5), integrated nucleus (OR 0.6, 95% CI 0.4-0.9), low family poverty (OR 0.5, 95% CI 0.3-0.8), and high family poverty (OR 5.3, 95% CI 1.5-18.6). From the perception of the tutor: the single parent (OR 1.9, 95% CI 1.09-3.4), and high family poverty (OR 2.9, 95% CI 1.1-7.7). There were 259 families with concordant perception of family function/dysfunction with a Kappa = 0.189, determining that the types associated are: simple nuclear (OR 0.4, 95% CI 0.2-0.7), single-parent (OR 1.7, 95% CI 0.80-3.8), integrated nucleus (OR 0.5, 95% CI 0.3-0.8), non-integrated nucleus (OR 1.9, 95% CI 1.09-3.5), and high family poverty (OR 13.8, 95% CI 1.7-108.5). CONCLUSION: The family types with adolescents associated with family dysfunction are single-parent families with a non-integrated nucleus and high family poverty, and as protective factors, the simple nuclear and integrated nucleus
